What A Difference A Day Makes

Over the past few months, the big health related news was the Institute of Medicine's report regarding the increasing percentage of obese Americans. The expected increased girth of the nation raised alarms because of all the other medical problems that are likely to ensue.  Unfortunately, we will not have to wait because a new medical report by Virginia Fried and colleagues was just released by the U.S. National Center for Health Statistics, part of the U.S. Centers for Disease Control and Prevention. The report titled, NCHS Data Brief, "Multiple Chronic Conditions Among Adults Aged 45 and Over: Trends Over the Past 10 Years," is truly frightening. 

According to new research, between 1999-2000 and 2009-2010, the number of Americans aged 45 and older with two or more chronic conditions has grown, with senior citizens especially at risk of developing both diabetes and high blood pressure. The study reveals that the percentage of Americans in the 45 to 64 year age group with two or more of the conditions grew from 16 percent to 21 percent and in the 65 and older age group, the percentage increased from 37 percent to 45 percent.

The report also revealed that 23 percent of adults aged 45 to 64 with at least two chronic conditions -- out of the list of nine -- either didn't receive necessary medical care or delayed it because of cost. That's up from 17 percent a decade earlier. The percentage of people in that group who didn't get necessary prescription drugs due to cost also grew from 14 percent to 22 percent over the period. Isolating individual conditions in people aged 45 or older, high blood pressure grew from 35 percent to 41 percent, diabetes from 10 percent to 15 percent, and cancer from 9 percent to 11 percent.

The most troubling part is that these numbers are expected to get even worse.  But I have reason for hope because of someone I spent time with today.

I met with a patient of MDPrevent today who has been participating in our LEAN Weight Loss program.  Prior to starting the program, her cholesterol was about 230, her fasting blood sugar was around 120, and her body mass index (BMI) was over 30. In the span of a few months, she has shed 16 pounds, dropped her BMI to 27.5, dropped her cholesterol to the 160s, and her fasting blood sugar to around 105. She accomplished this without any medications, surgery or supplements. She did it simply by changing the way she eats based on what she learned in our program. The best news is that her program was covered 100% by Medicare so it didn't cost her a penny.

Starting a new practice over the past couple of years has had its challenges. However, today it all came together when I witnessed first-hand again what a profound effect a change in lifestyle can have on someone's health. I am so proud to be part of such an effort and take great satisfaction in knowing that our team of Preventioneers are truly making a difference one life at a time. The best news is that our program is covered 100% by Medicare for those who qualify.

Is Obesity A Problem?

You probably think you know the answer to this question. From a medical perspective, your answer probably evolves around the fact that obesity leads to the development of chronic diseases such as diabetes, heart disease, cancer, dementia, arthritis, etc. These diseases lead to costly medical care which still leads to premature death. That sounds like a problem.

Well, based on a new study from the University of California Davis published in the Journal of the American Board of Family Medicine, you may be wrong. The study, which tracked 50,994 Americans between the ages of 19 and 90 for a total of six years, suggests that obesity itself may not be a harbinger of impending death; rather, hypertension and type 2 diabetes, which are often associated with obesity, are what leads to an early meeting with the grim reaper.

You may ask isn't that a question of semantics? Aren't obesity, diabetes, and hypertension so closely related that they may be considered one and the same? Isn't diabesity, as some call it, the right name for it? The answer may surprise you.

The study showed that obese people without these conditions were no more likely to die than non-obese people, and non-obese people with these conditions were more likely to die than obese people without them. So it's not weight per se that kills you, but the diseases that often, but not always, accompany excess weight.

In fact, in my practice I have seen many people who did not suffer from a weight problem, but were still struggling with diabetes. Well, that seems to make sense because weight itself is not the main factor in the development of diabetes and some people who are naturally heavier than others, still seem to enjoy good health.  (I remember many years ago when I worked in a summer sleep-away camp that there was a rather heavy young man that was an incredible athlete. He moved faster and stronger than most of his leaner peers. One would be hard pressed to say that he was unhealthy.) 

Nonetheless, this California study is consistent with a new movement that advocates HAES, which stands for Healthy At Every Size. The HAES camp believes that your health is more important than your size or body mass index (BMI) and I agree.

From the inception of MDPrevent, I have been telling patients not to focus on their weight loss; rather, I have been teaching, begging, exhorting, cajoling, and a number of other words ending in 'ing' to improve their health by eating certain foods and avoiding others, by staying more physically active all day long, by taking steps to ensure a good night's rest, and by developing strategies to manage stress effectively. My lectures often also focus on the need for a strong social network, the benefits of engagement and purpose, and the value of surrounding yourself with like-minded individuals. So, yes, one study doesn't prove anything, but it's not the first study to show the wisdom of focusing on your health and not your weight.

So now you may be thinking that obesity is not a problem, but you would be wrong. Obesity is still often associated with the predominance of chronic disease development. Even in the Albert Einstein College of Medicine study that identified Eastern European Jews who seem to have a longevity gene and who claimed to eat whatever they want, the results showed that those who survived into their 90s were almost always lean. Perhaps they had a genetic predisposition to being lean, but again, lean won almost every time.

I think the most serious reason obesity is a problem is because we don't as a society really seem to understand it. Quite frankly, my head is spinning from reading all the studies and books that purport to have defined, if not offered the perfect solution, to the problem. The list is almost endless.

Here's my abridged version of solutions offered (not saying they work or don't work; just listing to make a point):

Don't eat processed foods that contain white sugar and flour, avoid almost all carbs even the complex ones in fruits, eat more proteins, be a Vegan, eat more meat, drink more dairy, avoid saturated fats, avoid gluten, drink more water, balance your energy intake and output, don't live near fast food restaurants, eat more smaller meals, snack, don't snack, use small plates, eat breakfast within 30 minutes of waking up, don't eat breakfast until after you exercise, don't eat past seven at night, take dietary supplements that speed up metabolism, avoid anything other natural foods, stay physically active all day, go to Weight Watchers, follow the Adkin's diet, the South Beach Diet, the Zone Diet, the Cookie Diet, the grapefruit diet and countless other diets, take HCG and other appetite suppressants, take medications like Orlistat or Tenuate, have lap-band or stomach bypass surgery, etc.

Yes, there are quite a number of pundits that feel they have the solution, and that's a huge problem. Given so many choices, analysis paralysis sets in and we end up doing nothing or a little of this and a little of that, and that my friend is what I think is the biggest problem with obesity.

At this point, after reading countless books, articles, and studies, watching documentaries, attending conferences,  speaking to thought leaders, and working with patients, my solution is simple. Pick something that you think you can live with that has at least some decent science supporting it and STICK WITH IT. Getting healthy and losing weight takes time to do it right. It takes effort and concentration and it doesn't happen overnight. For many it will be a life-long struggle. Sacrifices will have to be made. Favorite foods may need to be given up perhaps forever. Trade-offs will be made and battle-lines drawn. That's the reality of the situation for most and I challenge anyone to prove otherwise.

If you need support, get it. If you are a do-it-on-your-own type of person, that's fine, but have a plan and follow it religiously.

If you are looking for some direction and/or insight, here's my suggestions: avoid processed foods, stay active during as much of the day as possible, drink fluids to keep your urine a pale yellow, don't take any pills you don't absolutely need to take, make fruits, vegetables, beans, nuts, and whole grains the bulk of your diet, eat some wild salmon at least 2-3 times a week, get at least 7 hours sleep a night, learn how to manage stress better, nurture relationships, and find something that gives you pleasure to engage in consistently both physically and mentally.

If you follow this advice, I can't promise what weight, if any, you will lose, but I'm pretty sure you will be healthier than you are now. In the final analysis, I hope you agree that being healthy is the most important goal.

Pressure Rising But Not As Fast As Costs

Trying to learn all I can about evaluating clinical studies, I recently completed a book aptly titled, "Evaluating Clinical Research, All That Glitters Is Not Gold," by Bengt Furberg and Curt Furberg.  

Suffice it to say that I learned a lot from this book about what to look for in a study to determine if it offers valuable and practical data. One of the examples repeatedly used in the book to show how data can be manipulated refers to studies of blood pressure medications. The book reveals numerous examples of how many of the new hypertensives have shown little benefit over the long used, inexpensive diuretics as a first line therapy for high blood pressure. Diuretics reduce your body's fluid volume, which often reduces blood pressure. I didn't think much about these examples because I haven't look at the full body of research on blood pressure control medication so I read about them with a passing fancy.


So when I came across an interesting article yesterday titled, "Rethink Pills for Hypertension," on a Canadian website, it caught my attention.

Here's the article: http://www.thestarphoenix.com/health/Rethink+pills+hypertension/6885891/story.html#ixzz1zqEgqhvd


The gist of the article is that while new medications have substantially raised the cost of treating hypertension, hypertension continues to increase across the Canadian population. Of course, there can be many reasons for more hypertension including increasing heart disease, diabetes, obesity, etc.

Nevertheless, the article reports, "In a study published in the Canadian Medical Association Journal, the authors documented that the cost for these medications rose to $5.3 billion in 2006 from $1.7 billion in 1996. The cost per 100,000 population rose to $17.5 million from $5.8 million during that 10-year period. The authors observed no plateau in spending and concluded that the rapid escalation in costs threatens the sustainability of public drug insurance programs."

So what's the problem? According to the article, "Of the 88 new patented drugs used during the study period, only 20 per cent offered a new active substance, let alone an actual clinical improvement...The first issue is that cheaper diuretics actually are superior to anti-hypertensive medications in treating high blood pressure. "

The article also shared the following study results, some of which were also discussed in my book; please note that I have not independently verified these studies.

"The Cochrane Collaboration performed a meta-analysis and found that no other drug class improved health outcomes better than diuretics. An interesting part of this analysis was that low doses of diuretics prevented coronary heart disease by 28 per cent and mortality by 11 per cent, while higher doses of diuretics did not. This same review also found that more expensive beta blockers and calcium channel blockers were not effective in reducing coronary heart disease and mortality. There were 14.8 million prescriptions filled in 2006 alone for beta blockers. The authors of the review concluded that low dose diuretics should be the first choice of drugs for patients with high blood pressure, and that it is fortunate that diuretics also are very inexpensive."

Furthermore, the article reports that "The Cochrane Collaboration published four meta-analyses on the effectiveness of anti hypertensives in reducing blood pressure. ACE inhibitors, alpha blockers, ARBs and beta blockers all reduce systolic blood pressure by a range of seven to eight points, and diastolic blood pressure by a range of five to six points. However, in these systematic literature reviews, the average blood pressure prior to treatment was 157/101 mmHg. As such, these medications reduced blood pressure to only 149/96 - well above the target of 120/80." That's not much of an improvement and leaves blood pressure too high for comfort.

The conclusions of the article are essentially that instead of using new (actually, not always new chemicals) expensive, patented blood pressure lowering drugs, doctors as a first-line therapy should stick with the tried and true, and very inexpensive, diuretics because they work as well if not better.

According to Mark Lenstra, the author of the article, if the new drugs showed limited benefit in a carefully controlled study where complianace is high and you expect the best results, what can you expect in the real world where there is less compliance. I don't share that concern because I believe that a drug should be evaluated based on when it is actually taken and not on what happens when someone doesn't take it.

Nevertheless, I have to agree with Mark's original premise that it may be time to reconsider leapfrogging over diuretics as a first line therapy to more expensive, but no more effective, patented drugs. Combining the data from the book I just finished and these studies, that would seem to be the logical conclusion.

Although diuretics are by no means perfect, I think I will give them a more careful consideration moving forward in initially treating a patient's high blood pressure.

Pressure Rising...

Although the rising obesity epidemic has become a hot topic, it should not be the only widespread concern. There is another health phenomenon that does not get enough attention. It is the incidence of high blood pressure, or hypertension (HTN). The most common reference to high blood pressure usually comes in the form of warnings to curtail your salt intake.

While salt levels in your blood stream are one mechanism that affects your blood pressure, it is not alone.

Here's a quick primer on high blood pressure and its common causes.

It all starts with your heart and your arterial blood vessels. HTN is affected by how your heart is pumping, how much it is pumping, and what it is pumping against. So if your arteries, which are the blood vessels your heart pushes blood through to get it to your organs, are narrowed because of arteriosclerosis or spasm, your pressure goes up. If your blood volume is increased because of water retention, your pressure also goes up.

Blood pressure is also affected by neurological systems called the autonomic system, which is controlled by the brain.  Although it's role is not perfectly understood regarding its contribution to HTN, it is known that the system can raise and lower your blood pressure by sending signals to blood vessels to narrow or dilate. This system is also called the "fight or flight" system because it controls your body's reaction to external factors.

Your kidneys are believed to play a major role in HTN. First, kidneys regulate fluid balances in your body by controlling how much fluid and salt is excreted to maintain a good circulating fluid volume. If you ingest more salt, the kidneys are suppose to excrete more salt to keep the balance.

The kidneys also release a hormone and enzyme called renin, which perhaps plays a very significant role in fluid maintenance and blood vessel control as part of the renin-angiotensin-aldosterone axis. This axis is the body's system that ultimately controls one of the kidney's main functions--to excrete excess sodium and potassium. The amount of two elements in your body affects how much water the body retains. This axis also controls the flexibility of blood vessels walls and has the ability to narrow the blood vessel when beneficial to the body. Obviously, if the system malfunctions and blood vessels narrow inappropriately, this can cause HTN.

HTN is deadly to your body because of the extra strain it puts on your always pumping heart to work harder. This can lead to the growth of heart-muscle, which is not a good thing. As the heart works harder, it can grow larger and actually become flabby and dysfunctional. Untreated, this often leads to heart failure and eventual death.

So when a doctor confronts HTN, the first instinct, if not rule, is to lower it with medication(s) to prevent any damage. There are many types of medications to treat HTN, including diuretics which simply cause the kidneys to excrete more fluid, calcium channel blockers,beta-blockers, vaso-dilators etc.  Unfortunately, many doctors do not effectively address many of the root causes of the rising blood pressure such as stress, eating the wrong foods and avoiding the right ones, weight gain, etc. This brings to mind one of my favorite childhood anecdotes.

My father drove an old car and one day a red light went on in the dashboard. We drove to a gas station and my father asked if they could address the problem. They said sure, we can "disconnect the red light."  It seems that when it comes to high blood pressure, doctors often disconnect the red light with medication rather than address why the red light went on in the first place.

This morning, I received an email from a website called REALAGE.com.  The website is now owned by sharecare.com, which is partially owned by Dr. Oz (yes, him again).  Clicking on the link and probing around the website, I found an article titled Reduce High Blood Pressure with Yogurt. The article claims that yogurt and low fat dairy can reduce high blood pressure. To quote the article, "In a recent study, a diet that was rich in low-fat dairy seemed to help curb the risk of high blood pressure by as much as 31 percent."

Wow, that sounds pretty good, but it couldn't be more misleading. I previously blogged about that study (Want Milk?, Friday April 20, 2012, http://mdprevent.blogspot.com/2012/04/want-milk.html). It showed that compared to eating dairy with a higher fat content, there was a decrease in blood pressure by eating low-fat dairy. The study did not look at how low fat dairy compared to no-fat dairy and no dairy altogether. Telling you something is the lesser of two evils without telling you what it is compared against I believe is misleading.

I guess by now, you may not be surprised that health information provided by anything connected to Dr. Oz may be misleading.  If you want to lower your blood pressure, learn what foods to eat and which to avoid, and most importantly get the right type of exercise, a good night's rest, and manage your stress effectively. All of these affect blood pressure. Either way, always consult a doctor if you have high blood pressure, rather than a website or TV show that may be misleading. Accurate information allows you to make informed choices. Isn't that what you want?

MDPrevent